Jaap A Joles Selected Research

Molsidomine (SIN 10)

12/2010	The nitric oxide donor molsidomine rescues cardiac function in rats with chronic kidney disease and cardiac dysfunction.
7/2010	Perinatal micronutrient supplements ameliorate hypertension and proteinuria in adult fawn-hooded hypertensive rats.
6/2008	A perinatal nitric oxide donor increases renal vascular resistance and ameliorates hypertension and glomerular injury in adult fawn-hooded hypertensive rats.
4/2004	Hypercholesterolemia in rats induces podocyte stress and decreases renal cortical nitric oxide synthesis via an angiotensin II type 1 receptor-sensitive mechanism.
5/2002	Proteinuria is preceded by decreased nitric oxide synthesis and prevented by a NO donor in cholesterol-fed rats.

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Jaap A Joles Research Topics

Disease

37	Hypertension (High Blood Pressure) 01/2021 - 12/2001
28	Chronic Renal Insufficiency 05/2021 - 10/2007
19	Type 2 Diabetes Mellitus (MODY) 01/2022 - 01/2016
18	Proteinuria 01/2020 - 04/2000
17	Inflammation (Inflammations) 01/2020 - 02/2001
15	Fibrosis (Cirrhosis) 01/2021 - 06/2010
11	Chronic Kidney Failure (Chronic Renal Failure) 04/2021 - 04/2004
10	Overweight 01/2022 - 01/2016
8	Hypoxia (Hypoxemia) 01/2019 - 02/2013
7	Ischemia 01/2020 - 12/2001
6	Renal Insufficiency (Renal Failure) 05/2021 - 02/2001
6	Heart Failure 01/2021 - 11/2006
6	Albuminuria 01/2020 - 09/2007
6	Diabetic Nephropathies (Diabetic Nephropathy) 01/2019 - 06/2006
6	Cardio-Renal Syndrome 01/2019 - 11/2006
5	Cardiovascular Diseases (Cardiovascular Disease) 11/2020 - 03/2002
4	Acute Kidney Injury (Acute Renal Failure) 04/2021 - 02/2013
4	Kidney Diseases (Kidney Disease) 01/2020 - 04/2004
4	Anemia 01/2019 - 11/2006
4	Disease Progression 10/2017 - 08/2010
4	Hypercholesterolemia 12/2005 - 04/2000
3	Hypertriglyceridemia 04/2022 - 04/2000
3	Body Weight (Weight, Body) 01/2021 - 12/2017
3	Left Ventricular Dysfunction 09/2020 - 12/2010
3	Renal Hypertension 01/2020 - 12/2001
3	Pre-Eclampsia (Preeclampsia) 01/2020 - 11/2017
3	Myocardial Infarction 01/2016 - 02/2008
3	Sepsis (Septicemia) 02/2013 - 08/2010
3	Glomerulonephritis 01/2012 - 08/2007
2	Insulin Resistance 01/2022 - 01/2020
2	Hyperglycemia 01/2022 - 01/2020
2	Calciphylaxis 01/2021 - 03/2016
2	Cardiomegaly (Heart Hypertrophy) 01/2021 - 01/2020
2	Birth Weight (Birth Weights) 08/2020 - 01/2019

Drug/Important Bio-Agent (IBA)

18	Nitric Oxide (Nitrogen Monoxide)FDA Link 01/2021 - 12/2001
11	Proteins (Proteins, Gene)FDA Link 01/2020 - 05/2002
10	CreatinineIBA 04/2021 - 01/2012
9	Angiotensin IIIBA 01/2021 - 03/2004
9	SaltsIBA 01/2021 - 12/2011
8	Nitric Oxide Synthase (NO Synthase)IBA 01/2020 - 12/2001
7	Reactive Oxygen Species (Oxygen Radicals)IBA 04/2022 - 04/2005
7	Glucose (Dextrose)FDA LinkGeneric 01/2022 - 10/2017
7	Urea (Carbamide)FDA LinkGeneric 04/2021 - 02/2008
7	Connective Tissue Growth FactorIBA 01/2015 - 06/2006
6	Hydrogen Sulfide (Sulfide, Hydrogen)IBA 01/2021 - 03/2015
6	Glucagon-Like Peptide-1 ReceptorIBA 01/2021 - 01/2016
6	AlbuminsIBA 01/2018 - 03/2006
5	Metformin (Glucophage)FDA LinkGeneric 01/2022 - 12/2017
5	Arginine (L-Arginine)FDA Link 01/2021 - 02/2001
5	Antihypertensive Agents (Antihypertensives)IBA 01/2021 - 05/2004
5	Biomarkers (Surrogate Marker)IBA 11/2020 - 09/2008
5	Molsidomine (SIN 10)IBA 12/2010 - 05/2002
4	dapagliflozinIBA 01/2022 - 01/2020
4	Gliclazide (Diamicron)IBA 01/2022 - 01/2020
4	Sodium-Glucose Transporter 2 InhibitorsIBA 01/2022 - 01/2020
4	Sodium-Glucose Transport ProteinsIBA 05/2021 - 01/2020
4	Angiotensin-Converting Enzyme Inhibitors (ACE Inhibitors)IBA 01/2021 - 02/2004
4	Liraglutide FDA Link 01/2021 - 11/2016
4	Oxygen (Dioxygen)IBA 01/2020 - 01/2015
4	Erythropoietin FDA Link 01/2019 - 11/2006
4	lixisenatideIBA 01/2019 - 12/2017
4	insulin glulisine FDA Link 01/2019 - 12/2017
4	CholesterolIBA 09/2011 - 04/2000
4	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 08/2010 - 02/2008
3	Pharmaceutical PreparationsIBA 01/2022 - 01/2020
3	Sitagliptin Phosphate (Januvia)FDA Link 01/2021 - 11/2016
3	AngiotensinsIBA 01/2021 - 07/2009
3	ReninIBA 01/2021 - 07/2009
3	Losartan (Cozaar)FDA LinkGeneric 01/2021 - 02/2004
3	sodium thiosulfate FDA Link 01/2021 - 01/2020
3	Dipeptidyl-Peptidase IV InhibitorsIBA 11/2020 - 11/2016
3	CitrullineIBA 08/2020 - 12/2007
3	SodiumIBA 01/2020 - 07/2003
3	Hemoglobins (Hemoglobin)IBA 01/2020 - 07/2010
3	Exenatide (Byetta)FDA Link 10/2019 - 01/2016
3	Glucagon-Like Peptide 1 (GLP 1)IBA 01/2019 - 11/2016
3	Insulin Glargine (Lantus)FDA Link 01/2019 - 12/2017
3	salicylhydroxamic acid (SHAM)IBA 01/2017 - 01/2011
3	EnzymesIBA 03/2016 - 03/2015
3	CollagenIBA 09/2012 - 02/2008
3	Messenger RNA (mRNA)IBA 09/2011 - 11/2008
2	glimepiride (Amarel)FDA LinkGeneric 01/2022 - 11/2020
2	Uric Acid (Urate)IBA 01/2022 - 04/2020
2	Insulin (Novolin)FDA Link 01/2022 - 11/2016
2	LinagliptinIBA 01/2022 - 11/2020
2	AntioxidantsIBA 01/2021 - 10/2017
2	AldosteroneIBA 01/2021 - 09/2007
2	Drinking WaterIBA 01/2021 - 01/2020
2	Dipeptidyl Peptidase 4 (Dipeptidyl Peptidase IV)IBA 11/2020 - 10/2017
2	Matrix Metalloproteinases (MMPs)IBA 09/2020 - 11/2008
2	Inulin FDA Link 01/2020 - 01/2020
2	p-Aminohippuric Acid (p-Aminohippurate)FDA Link 01/2020 - 10/2019
2	ThiosulfatesIBA 01/2020 - 03/2016

Therapy/Procedure

13	Therapeutics 05/2021 - 05/2004
5	Nephrectomy 01/2021 - 01/2012
5	Denervation 11/2020 - 07/2012
4	Transplantation 12/2021 - 08/2007
3	Renal Replacement Therapy (Therapies, Renal Replacement) 04/2021 - 10/2007
3	Kidney Transplantation 01/2020 - 01/2015
2	Glycemic Control 12/2020 - 01/2020